Cytokine Storms May Fuel Some COVID Deaths

Doctor Mukesh Kumar, PhD,  a virologist and immunologist at Georgia State University in Atlanta, studies how the body responds to infections.

In experiments in his high-security lab, he has been infecting cells and animals with SARS-CoV-2 to learn what happens.

A great article on WebMD by Brenda Goodman, MA, refers to Doctor Kumar in describing how a cytokine storm works.

One thing Dr. Kumar has observed is that the virus copies itself very quickly once it infects a cell.

“That’s a lot of stress on the cell in a small amount of time,” Kumar says.

The cell begins to send SOS signals.

“When any cell senses that there is something foreign, that there is something bad happening, the immediate response of the cell is to kill itself,” he says, “It’s a protective mechanism so it doesn’t spread to other cells.”

Certain kinds of cytokines trigger cell death. When you have many cells doing this at the same time, a lot of tissue can die. In COVID-19, that tissue is mostly in the lung. As the tissue breaks down, the walls of the lungs’ tiny air sacs become leaky and fill with fluid, causing pneumonia and starving the blood of oxygen.“Basically, most of your cells will die because of the cytokine storm. It eats away at the lung. They cannot recover,” Kumar says. “It seems to play a role in death in a large number of cases.”

When the lung becomes greatly damaged, respiratory distress syndrome follows. Then other organs start to fail.

Kumar says the amount of cytokines he sees being produced by cells in response to a SARS-CoV-2 infection is about 50 times higher than he has seen in response to Zika or West Nile virus infections.

See entire very informative article originally published on 17 April 2020:
https://www.webmd.com/lung/news/20200417/cytokine-storms-may-be-fueling-some-covid-deaths


12 thoughts on “Cytokine Storms May Fuel Some COVID Deaths”

  1. It’s my understanding that the SARS-COV-2 virus has yet to be isolated and purified (per Koch’s postulates), so where did this doctor get a sample of the actual virus for the purpose of “infecting cells and animals” ?

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  2. Natural defenses seem to be the best defenses.
    What I’ve been doing is;
    Lost weight (I used keto and lost 100lbs in a year)
    Multivitamin with zinc daily
    Vitamin D2 daily
    Lots of sunshine and fresh air
    Stay hydrated
    Vigorous outdoor exercise daily
    Cut back on the booze
    Get plenty of sleep. A solid 8 hours a night
    I don’t smoke anymore but if I did I’d quit

    I am not afraid to take the vaccine. Lord knows I had thousands of jabs in the military without any serious side effects.
    But I am not elderly, or essential (so to speak) so I’ll wait till those that need it get it.

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  3. Thanks for posting that article. That is something to think about at great length.

    Maybe “less” really is more, in re: this virus.

    Reply
  4. One of the feared consequences of the covid vaccination is
    autoimmune disease. Among those citing this possibility is Dr. Yeadon, previously scientific advisor Pfizer, and Professor Wodarg, former chair of the Council of Europe Parliamentary Assy on Health.

    “Heidi Neckelmann says obstetrician Gregory Michael, 56 – her ‘best friend’ and partner of 28 years – was active, healthy and had no pre-existing conditions before getting the jab on December 18.

    “However he died from a stroke Sunday morning after suddenly developing a rare autoimmune illness that causes the body to destroy its own platelets, the tiny fragments that help blood to clot.
    “Dad-of-one Gregory suffered no immediate reaction to the injection but three days later he was taking a shower and noticed petechiae – spots of red that indicate bleeding beneath the skin – on his feet and hands.
    “In people with ITP, also known as severe thrombocytopenia, the immune system mistakes platelets for foreign objects and instructs the spleen to destroy them.”
    –msn.com

    The disease is triggered in the aftermath of other conditions. He had none of them. One case doesn’t make a pattern. We’ll have to wait and see if there are more.

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  5. It’s been found that low zinc levels suppress cytokine production… that’s not a good thing, as the virus-infected cells then don’t receive the signal to die, and continue pumping virus out to infect other cells. So apparently zinc is critical to producing the cytokines.

    Low zinc levels have also been found to be a cause of the loss of the sense of smell (and taste, since the two are so closely intertwined) from CoV19 infection… so it may be that the body is attempting to create cytokines to kill off infected cells, ran low on zinc, with a side effect of that being the loss of the sense of taste or smell.

    Again, using quinine (Q) or chloroquine (CQ) or hydroxychloroquine (HCQ) inhibits the ACE2 enzymatic pathway by which the virus can attach to cells.

    The problem with earlier Q / CQ / HCQ studies is that some variants of the virus can use another enzymatic pathway… the TMPRSS2 pathway.

    So to fully block the virus from infecting cells, one must use an ACE2 inhibitor along with a TMPRSS2 inhibitor such as camostat mesylate.

    One needn’t go to a doctor to get quinine… you can receive sufficient dosage from quinine-fortified Indian Tonic Water, available in your supermarket. Quinine content is limited in the US to 83 mg / l, and that’s sufficient to limit infectivity by an average of ~50% (varying between ~40% and 60% just before and just after each dose is taken).

    That’s enough to knock down the infectivity of the virus such that your immune system can clear the virus without also dealing with a rapidly-spreading infection.

    But to get camostat mesylate, you’ll need a doctor. I’ve not researched natural substances which would have TMPRSS2 enzyme inhibitors, as I’ve already had the virus. I didn’t use a TMPRSS2 inhibitor, and apparently the virus variant I caught couldn’t use that enzymatic pathway.

    I had been pre-dosing with 83 mg/day of quinine (1 l of Indian tonic water / day) for ~3 weeks before I caught the virus. It only takes ~5 days for quinine levels to build up in your body such that you’ve got full prophylactic effect.

    I had a loss of sense of taste, a slight tickle in the back of my throat, and absolutely no energy. It hit pretty fast… in the morning, I felt fine, by 9:30 am the tickle in the back of my throat was there. I noticed at lunch that I couldn’t taste anything. By 1:30 pm, I didn’t have any energy. I went home after work, loaded up on vitamin C (I took 2x RDA), vitamin D (RDA), vitamin E (RDA), zinc (RDA) and drank a liter of Indian tonic water. Then I took as hot a shower as I could stand, then piled under a thick stack of blankets and sweated it out.

    My sense of taste returned the next day, as did my energy. The tickle in my throat went away about 12 hours after that.

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  6. Question: So those infected with corona should be given oxygen? While ventilators would act as a kind of catalyst and speed up the spread of infection?
    Is my thinking correct?

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  7. Id reckon(with no way to test it) that the cytokine storms from covid are very much similar to the ebola caused ones
    fast replicating virus, similar overload to organs, brain swelling leakages as well as veins eyes etc from what been mentioned over the months via web releases etc
    thats why dexamethasone helps

    Reply
  8. Another good find. The UK has just allowed another two – expensive – rheumatoid arthritis drugs to be used on Covid cases. Strangely enough you can buy HCQ on the internet which is sold as a treatment for…wait for it….rheumatoid arthritis. There seems to be far too much avoidance of cheap non-patent treatments going on not to think there is some form of corruption going on, certainly in our NHS.

    Reply
  9. So many government paid medics, scientist, statisticians, etc., appear to totally misunderstand that healthy people have immune systems that still function, apparently work very well even against this virus outbreak. If it were not so then national death rates, or more correctly excess mortality rates, would be orders of magnitude more than a bad seasonal flu outbreak.

    Reply

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