You can use tonic water to fight Covid-19, says reader

Any medical professional out there who would like to weigh in on this?
_________

You can use tonic water to fight Covid-19

Clyde Mason

You don’t have to get a prescription for hydroxychloroquine… that’s a pro-drug form of chloroquine, which is a non-enzymatically bio-activated form of quinine.

And you can get quinine from your local supermarket… Indian tonic water in the US contains a maximum 83 mg / l.

That’s the same stuff used to make gin and tonic. It was originally used to combat malaria in India, and the British colonizers at the time added gin to cut the bitter taste, giving us gin and tonic. I prefer the orange-flavored tonic water, but I find the lime-flavored tonic water to be extremely foul. I never did like lime flavor. There’s lemon flavor, too, but I don’t like lemon, either.

83 mg / day (1 liter per day) of Indian tonic water is enough to give you approximately 50% reduction in infectability, allowing your immune system to clear the virus without also dealing with a rapidly spreading infection.

In the body, since HCQ and CQ are broken down into quinine, it’s the quinine which is the active ingredient anyway… it’s just that CQ and HCQ are more-complex molecules, and take longer to break down, allowing longer dosage schedules. Quinine half-life is ~18 hours in the body, so I drank 500 ml of tonic water in the morning, and 500 ml at night.

If you’re taking it for prophylactic purposes, it takes ~5 days for the quinine to build up to the point that your body is excreting as much as you’re taking in.

Quinine inhibits the ACE2 enzymatic pathway by which the virus can attach to and infect cells. There’s a variant of the virus which can also use the TMPRSS2 enzymatic pathway (that’s why some of the HCQ trials didn’t work very well… to get full protection against that virus variant, you have to inhibit both enzymatic pathways), so if you’re using quinine prophylactically and you still get sick, go to your doctor to get a TMPRSS2 inhibitor such as camostat mesylate.

It works. I got the virus variant that could only use the ACE2 enzymatic pathway, and was over it in 2 days with only minor symptoms… it wasn’t even as bad as a mild cold.


34 thoughts on “You can use tonic water to fight Covid-19, says reader”

  1. Thanks for this.

    I have been drinking 250 ml of Indian tonic water since I read that quinine inhibited corona virus. together with effervescent vit C.

    I will now increase my dose !!!

  2. Cash Payments Being Offered Medical Personnel to Take the Vax

    Houston Medical Hospital is offering $500 to $26,000 employees. That’s $13 million; wonder who’s paying for it; probably us. Graceland Nursing Home is paying $750, paid for by Fed govt.

    L.A. Fire Dept is offering firemen raffle prizes– gift cards, home security cameras, bikes– what, no toasters?

    https://thevaccinereaction.org/2021/01/health-workers-and-emergency-responders-offered-incentives-to-get-covid

  3. Actually, you can’t prove that it worked, because all you know is that you got better quickly, whilst consuming tonic water.

    By all means test it properly, but one person taking the drink and not suffering unduly doesn’t prove much to be honest.

    I’m all for finding someone to organise to test it properly though.

    • Or you could do your own research to figure out that studies have already been and currently are being conducted:
      https://journals.lww.com/ccejournal/Fulltext/2020/11000/Camostat_Mesylate_May_Reduce_Severity_of.16.aspx
      “Severe acute respiratory syndrome coronavirus 2 cell entry depends on angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) and is blocked in cell culture by camostat mesylate, a clinically proven protease inhibitor.

      The severity of coronavirus disease 2019 decreased upon camostat mesylate treatment within a period of 8 days and a similar effect was not observed in patients receiving hydroxychloroquine.”

      Of course, if the Covid 19 virus variant could use the TMPRSS2 enzymatic pathway, HCQ administration would have no effect, because HCQ inhibits ACE2 enzyme biosynthesis, not TMPRSS2 enzyme biosynthesis.

      https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009212
      “We also show that hydroxychloroquine efficiently blocks viral entry mediated by cathepsin L, but not by TMPRSS2, and that a combination of hydroxychloroquine and a clinically-tested TMPRSS2 inhibitor prevents SARS-CoV-2 infection more potently than either drug alone.”

  4. Don’t you remember that in the beginning it was said that alcohol would increase chances of infection? A direct shot at gin and tonics, which I’ve had everyday since March Indian Tonic pricy but just use cheaper gin. Don’t forget the lime.

  5. There was a run on tonic water at our local stores last spring, I think since then people have forgotten about it. I have several bottles in storage, but we tend to have strong immune systems so we have only used it when my husband has been exposed at work.

    • SARS Cov 2 uses your strong immune system against you. Quinine and Hydroxychloroquine are anti-inflammatories. They blunt the cytokine storm that this novel virus causes. Most pulmonary/infectious disease physicians are using dexamethasone for this purpose. Research into drugs such as colchicine, which we use for gouty arthritis show a strong effect in limiting damage that this virus initiates. The amount of quinine in the tonic water is miniscule and is probably ineffective.

  6. Being English, of course I’m taking quinine everyday from tonic water….add a bit of zinc and there you go…and it’s really cheap….

  7. Not a Doctor, but I followed up on this subject last spring. Quinine water or tonic water today, contains very small amounts of quinine. I believe quinine’s use is regulated due to its asserted potential side effects (or because there is no profit from natural cures). While true that chloroquine is a synthetically derived form of quinine, you’d have to drink gallons of tonic water to come close to a single dose of a single Rx pill, making it impossible to get enough quinine to do any good. It is true that ‘gin and tonic’ was a popular drink during the British Empire days when India and other ‘malaria’ prone parts of the world were ruled by Britain. I could not find any information on the quinine concentrations used in ‘tonic water’ then, but do know it was popularly given in powder form, mixed with water and sugar or other liquid, i.e., tonic water!

    • I did a whole paper on this when I did my research on the topic… based upon the clinically effective dosages of CQ and HCQ used in treatment of Covid 19, and given that effectiveness has a ‘decreasing return’ and plateaus at higher dosages (ie: even a small dosage has a large effect, whereas larger dosages have a succeedingly smaller additive effect), it is estimated that 83 mg / day of quinine, administered via a morning and an evening dose of 500 ml each of quinine-fortified Indian Tonic Water, would, immediately after ingestion, give ~60% reduction in infectivity, decreasing until 12 hours later (just before the next ingestion) to ~40% reduction in infectivity, the average being ~50%.

      I’m not in front of my home computer, but I can post the report I wrote up when I get home, if anyone wants it… it’s replete with references to corroborate the claims. It’s a long read, but informative.

  8. I work as a hospital x-ray technologist, which is far from being a doctor. This is not medical advice, just one man’s opinion.

    I read an article on this website about something called Glutathione being used successfully to treat covid-19. I checked and found out that Glutathione is cheap and available on Amazon. I ordered several containers.

    My daily “virusbuster mix” is
    Colloidal Silver nasal spray, Glutathione, Vitamin D, zinc, and 1-2 oranges for the vitamins A, C, and bioflavonoids.

    I read up on tonic water in early 2020, and concluded that today’s quinine levels in tonic water are way too low. I could not drink enough tonic water to get enough quinine.

    Peace from BC

    • Yes, I think colloidal silver would be more effective than the small amount of quinine that’s in tonic water.

    • In the US, tonic water is limited by law to a maximum of 83 mg/l. There are websites which show the quinine content of tonic water. I was lucky to live near a supermarket (Lucky) which carries a brand which has the maximum amount, sold in 2 l bottles.

      83 mg/day of quinine might not sound like much considering the dosages of HCQ used, but its efficacy isn’t a straight line… a small dosage has a larger effect, and successively larger dosages have successively smaller additive effect.

      On top of that, HCQ being a pro-drug form of CQ, and CQ being a non-enzymatically bioactivated form of quinine, the body excretes some of the HCQ (and subsequent CQ) before it’s ever bioactivated into quinine, so they *have* to use larger dosages just to get enough quinine… the main benefit of CQ and HCQ is that it takes longer for the body to break the molecules down into quinine. Quinine is rapidly absorbed by the body, so large dosages would cause side effects such as low blood pressure (the ACE2 enzyme up-regulates blood pressure). Those large dosages of CQ and HCQ, combined with the more-complex molecules, allow longer time periods between dosages. Quinine half-life in the body is only ~18 hours, so frequent dosages are required. That’s why in India, they made it a drink to combat malaria.

      So 83 mg/day of quinine (divided into two dosages of 500 ml of quinine-fortified Indian tonic water, one in the morning, one in the evening), based upon my research, will give ~60% reduction in infectivity immediately after ingestion, descending to ~40% reduction 12 hours later (immediately prior to the next ingestion of tonic water), giving an average of ~50%.

  9. I was prescribed HCQ to prevent malaria while working in the jungles of South America.
    It did not “KILL ME” like Neil Cavuto squealed at President Trump. There were no side-effects, as the Left-Wing-Hate-Machine spewed at us all.
    And I never contracted Malaria, despite living in a “hot spot” of same.
    Clearly Neil and his fellow Trump Haters have deprived thousands of people of a medicine that could have saved their lives!

    • Correct.
      True. Some people have a G6PD enzyme deficiency and Hydroxychloroquine can sicken or kill them. We test for that deficiency in the US military.

  10. Tonic water contains quinine, which is the main ingredient in Hydroxychloroquine. It is mainly used to treat malaria. Malaria binds itself to the red blood cells, preventing them from carrying oxygen. Covid does the same thing. The quinine prevents malaria and covid from latching on to red blood cells. Zinc assists quinine in this process.

    When the Brit were ruling over Africa, malaria was prevalent among the Africans. (as an aside, sickle cell evolved in Africans because malaria couldn’t bind to the sickle cells. Those who had sickle cell lived longer.) To prevent catching malaria, the Brits would have a gin and tonic every night. They would raise a glass and say “here’s to your health.”

    And now you know the origins of the “Here’s to your health” toast.

  11. Cheap and effective. I have known this for years. You can offer all the studies you want but many will never believe you. I pay no attention to them. I use it and it works for myself. It has been many years since I have had the flu. So long I can’t remember last time. Even for medical doctors compliance is a major issue. Cheap , effective and works. That is enough for myself.

    • Yes. Quinine / chloroquine / hydroxychloroquine has been found to be effective against SARS, MERS and the original Covid virus (can’t remember the year it hit)… considering that a good proportion of common colds are coronavirus, Q / CQ / HCQ is effective against them as long as the virus uses the ACE2 enzymatic pathway to attach to cells.

      https://pubmed.ncbi.nlm.nih.gov/16115318/
      “Chloroquine is a potent inhibitor of SARS coronavirus infection and spread”

  12. Ok, here’s the paper I’d written up as research when Covid 19 first came to prominence.

    I first searched how coronaviruses infect cells, and learned that in order for the virus to infect a cell, the cell must first ‘invite it in’ by supplying a pH gradient in the form of a sialic acid moiety (which all our cells do because ACE2 is the enzyme which up-regulates blood pressure).

    I then searched for the enzymatic pathways by which coronaviruses infect cells and learned it was via the ACE2 enzymatic pathway (the TMPRSS2 pathway was discovered later in another Covid 19 virus variant).

    I then searched for everyday products which would act as enzymatic inhibitors, leading me to quinine.

    After it was discovered that some variants of the Covid 19 virus can also use the TMPRSS2 enzymatic pathway, I researched everyday products which inhibit that, but didn’t find much, so I searched for prescription medication which does so, leading me to camostat mesylate.

    ———-

    Quinine is a natural product derived from the bark of the cinchona tree. It is rapidly absorbed in the body, which can cause side effects in large enough doses. It also has a half-life in the body of only ~18 hours, so frequent dosing is necessitated.

    Chloroquine is quinine produced synthetically and altered slightly to produce a new molecule for patenting purposes (naturally-occurring products could not be patented, and thus were not profitable to drug companies). The end product in the body is still quinine.

    Chloroquine is an amine acidotropic form of quinine that was synthesized in Germany by Bayer in 1934 and emerged approximately 70 years ago as an effective substitute for natural quinine [4]. Natural quinine was so cheap that mass production wasn’t sufficiently profitable until after 1941.

    Chloroquine is a non-enzymatically bioactivated form of quinine. Since the body must bioactivate it into quinine, it isn’t as rapidly absorbed as quinine, reducing to some degree the side effects due to rapid absorption. This also increases the half-life in the body, allowing less frequent dosage schedules.

    In acting against malaria, chloroquine becomes protonated after it passes through a cell wall. In Plasmodium Falciparum (the parasite causing malaria), chloroquine enters through the parasite’s digestive vacuole, becomes protonated, cannot pass back out of the digestive vacuole, builds up in the parasite, and prevents detoxification of heme, which increases acidity within the parasite to the point that the parasite is damaged. [15][16]

    Hydroxychloroquine is a prodrug form of chloroquine. It is metabolized in the body into chloroquine. The additional metabolic steps necessary to break down the molecule slows down the bioactivation of the resultant chloroquine into quinine (and hence the rate of absorption of the quinine), reducing toxicity caused by rapid absorption, but hydroxychloroquine is also ~1.6 to 8.8 times less active in the body against Plasmodium Falciparum. [15]

    https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7189851/bin/gr1_lrg.jpg
    (C) chloroquine, (D) hydroxychloroquine

    Quinine was used in India in the form of a drink known as Indian tonic water to treat / prevent malaria. The British, colonizing India at the time, added gin, giving us gin and tonic.

    By the 1930s Dutch plantations in Java were producing 22 million pounds per year of cinchona bark, or 97% of the world’s quinine production. When Japan invaded Java in 1941, natural quinine supplies dwindled, necessitating mass production of synthetic derivatives. [8]

    Quinine is eliminated mainly by hepatic metabolism [1]. Seven metabolites have been identified with 3-hydroxyquinine being the major metabolite [1]. Other majority metabolites are (10R)-10,11-dihydroxyquinine and (10S)-10,11-dihydroxyquinine [2].

    Quinine acts against malaria by targeting its purine nucleoside phosphorylase enzyme (PfPNP) [3], but it has other effects in the body which act against coronavirus.

    Namely, it targets angiotensin-converting enzyme 2 (ACE2) [4], interfering with sialic acid biosynthesis [4]. SARS, MERS and Covid-19 use sialic acid moieties as receptors, so quinine (and its synthetic counterparts) work to prevent viral attachment to cell receptors.

    https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7189851/bin/ga1_lrg.jpg

    Hydroxychloroquine / Chloroquine / quinine can also act on the immune system through cell signalling and regulation of pro-inflammatory cytokines. [4]

    It also acts to increase zinc uptake, which has anti-viral effects. Quinine used to be sold, prior to the FDA banning it for this use, as a treatment for leg cramps. The mechanism of action is increased uptake of zinc, calcium and magnesium by reducing hepatic metabolism [10]. Now it is recommended to directly ingest zinc, calcium and magnesium for leg cramps rather than taking quinine. [9]

    This may be why people infected with Covid-19 experience a loss of the sense of taste (and smell, since the two senses are intricately connected) [11][12]. They become acutely zinc deficient.

    It generally takes 4 to 5 days to completely flush quinine from the body [5]. The consumption of 10 oz. of tonic water can result in a quinine positive urine sample for a period of up to 96 hours (4 days) after intake. [5] Approximately 20% of quinine is excreted unmetabolized [6]. It has a half-life of approximately 18 hours [6].

    Quinine in tonic water in the US is limited to 83 mg / liter [7].

    Thus, we can make a simple linear extrapolation, assuming a half-life of 18 hours and ingestion of 83 mg / day. This means that after 24 hours, approximately 27.67% of the amount from the prior day remains in the system. Thus it accumulates until the body is excreting as much as is ingested. That occurs after approximately 5 days, when the in-body dosage varies between 124.5 mg immediately after ingestion to 41.5 mg immediately prior to the next ingestion.

    https://i.imgur.com/zYZFjYL.png

    Is that enough to have a prophylactic effect?

    Well, the National Institutes of Health state that chloroquine is “a potent inhibitor of SARS coronavirus infection” [4a][13] and since SARS binds to the same cell receptors as Covid-19, and since chloroquine is a synthetic version of quinine, it would appear that it should work.

    Pretreatment with 0.1, 1, and 10 μM chloroquine reduced infectivity by 28%, 53%, and 100%, respectively. [13]

    The EC90 value of chloroquine against the 2019-nCoV in Vero E6 cells was 6.90 μM, which can be clinically achievable as demonstrated in the plasma of rheumatoid arthritis patients who received 500 mg administration. [14]

    Interpolating the dosage of 500 mg to 6.9 μM concentration, for a dosage of 124.5 mg daily (83 mg from tonic water, the remainder being that remaining in the body from prior dosages), that should give a concentration of ~1.71 μM, reducing infectivity by ~60% immediately after ingestion of 1 L of Indian tonic water, decreasing over the next 24 hours to ~.47 μM, with a reduced infectivity of ~40%, per [13].

    That would be more effective at ‘flattening the curve’ than any measures taken thus far. Covid19 has a R0 of ~2.2… so we could conceivably reduce that (assuming an average reduced infectivity of 50%) to ~1.1, effectively completely ‘flattening the curve’.

    Given that no doctor is going to give you chloroquine or hydroxychloroquine as a prophylactic measure due to low supplies during a coronavirus pandemic, using Indian tonic water containing quinine to reduce infectivity would seem to be a prudent preventative measure.

    The wrap-up: It would appear that quinine interferes with sialic acid biosynthesis, which the Covid19 virus takes advantage of to attach to cell receptors. If the virus has a more difficult time attaching to cells, that allows the immune system to clear the virus without having to simultaneously deal with a rapidly-spreading infection.

    Addendum: It should be noted that Covid-19 (unlike SARS, MERS and the 2003 Covid virus) can utilize a second enzymatic pathway to infect cells. It is the TMPRSS2 enzyme pathway. So utilizing chloroquine or hydroxychloroquine to inhibit the ACE2 enzyme pathway, while also taking a TMPRSS2 inhibitor (camostat mesylate, for example) will act to more effectively block the virus’s ability to infect cells, thus allowing the immune system to clear the virus without also dealing with a rapidly-spreading infection. [17][18]

    [1] https://www.drugs.com/npp/quinine.html

    [2] https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2710.2007.00788.x

    [3] https://blogs.sciencemag.org/pipeline/archives/2019/01/22/quinines-target

    [4] https://www.sciencedirect.com/science/article/pii/S0924857920300881
    [4a] https://pubmed.ncbi.nlm.nih.gov/16115318/

    [5] https://friendslab.com/quinine-use-and-detection/

    [6] https://www.drugbank.ca/drugs/DB00468

    [7] https://en.wikipedia.org/wiki/Tonic_water

    [8] https://en.wikipedia.org/wiki/Quinine

    [9] https://healthfully.com/287838-leg-cramps-magnesium-calcium.html

    [10] https://www.webmd.com/drugs/2/drug-19765/cal-mag-zinc-ii-oral/details/list-interaction-details/dmid-455/dmtitle-aluminum-and-magnesium-antacids-quinidine-quinine/intrtype-drug

    [11] https://academic.oup.com/jn/article/131/2/305/4687001

    [12] https://www.businessinsider.com/coronavirus-symptoms-loss-of-smell-taste-covid-19-anosmia-hyposmia-2020-3?op=1

    [13] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/

    [14] https://www.nature.com/articles/s41422-020-0282-0

    [15] https://academic.oup.com/jac/article/52/2/188/719755

    [16] https://www.reddit.com/r/pharmacology/comments/6ehf0q/is_chloroquine_considered_a_prodrug/

    [17] https://www.biorxiv.org/content/10.1101/2020.07.22.216150v1.full.pdf

    [18] https://clinicaltrials.gov/ct2/show/NCT04321096

  13. Where the hell do you even get tonic water? I’ve never seen it anywhere or maybe I never had any reason to pay attention to it.

    • As far as I know, it’s available at almost every grocery store in the country. I drink it, not because it might help protect me from something, but merely because I like the taste.

  14. Quinine was first then chloroquine then hydroxychloroquine. Each being more effective order. I read that what is important is the reason they work. I seems that that “Hydroxychloroquine is a Zinc ionophore (binds Zinc and facilitate the entrance of that inside cells)”. There’s an over the counter treatment that does much the same. It’s the food ingredient Quercetin. I take it combined with zinc in the same capsule.

    “…If that is the case we could use other drugs against COVID that have the Zinc ionophore capability, such as Disulfiram and food supplements such as Quercetin (onion extract) and EGCG (green tea extract)…”

    From
    https://www.cancertreatmentsresearch.com/a-list-of-drugs-and-supplement-to-fight-coronavirus/

    I went to a large gathering and a few days later started having trouble breathing at night, I have respiratory problems anyways, but to be sure I used the before mentioned Quercetin, zinc, Lyper-spheric liposomal vitamin C, (it is a vit. C that can be taken directly into the blood stream because it’s Liponized into nano-particles), and then used Ivermectin I got from farm supplies for horses. Don’t laugh. It’s cheap and doctors just refuse to prescribe anything that is not 100% pushed by the drug companies and since there’s no money in this they never will. In a day I felt fine but continued with the same until the Ivermectin tube for a horse ran out to make sure. Did I have corona? I don’t know. If you go to the hospital they will grab you and probably not let go because the government is paying them some $30 grand a patient. They will also likely not allow any of the stuff I took and since it’s contagious I bet they would not let you leave. All I know is I felt fine later.

    None of the stuff I took has any adverse side effects that I could tell they only made me feel better.

    • Two different primary care physicians have told me that quercetin is indeed very helpful. It’s simply an herbal supplement, and is widely available over the counter.

  15. EGCG (green tea extract) and quercetin (onions & apples) have a similar mechanism to allow zinc into cells where it inhibits viral replication.

    If they had implemented this in August 2020 we’d have been done by the end of September. If they had done this in December after the senate appearance it would be OVER BY NOW. Eleven RCT’s WITH data (unlike their precious vaccine) show spectacular results.

    Ivermectin + Doxycycline + Zinc

    Professor Thomas Borody in August 2020 said:
    “It’s easier than treating the flu now”. “You can actually eradicate it”. “We know it’s curable”

    http://covexit.com/we-know-its-curable-its-easier-than-treating-the-flu-professor-thomas-borody/

    and the senate testimony by Dr. Pierre Kory (FLCCC Alliance, https://covid19criticalcare.com/ ) in early December.

    https://vimeo.com/490351508

    MURDER. This is MEDICAL MASS MURDER.

  16. Thanks Robert Felix for enabling such a useful forum of thoughts.
    I sometimes use inhaled hydrogen peroxide for upper respiratory tract infections. You have to be careful with peroxide and dilute it back to 0.1% or less as it can be quite oxidative of your body if used at too high a concentration or for too long at 0.1%.
    My excellent dentist makes all patients gargle with 1% H2 O2. In 30 seconds all the pathogens in the mouth and throat are oxidised beyond being infectious and if used daily will noble bacteria around your tooth/gum junction.
    I recommend Food Grade but the standard store purchased 3% solution with stabilisers works. One volume of 3% plus 3 volumes of water gives you about 0.75% solution.
    You might have to search a bit for a suitable nebuliser unit but you could just put the freshly diluted solution of 0.75% into a finger pump spray bottle and inhale the fine mist. Keep it refrigerated as it breaks down readily once diluted.

    I think Dr Mercola’s site recently published some protocols.

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